LEVELS – A Whole New Level Levels

The ketogenic diet is a low-carbohydrate, high-fat diet that has proven benefits for brain health. Research shows that the keto diet helps ease symptoms of some mental health conditions, including depression and bipolar disorder. But no diet, even keto, is one-size-fits all. Dr. Georgia Ede and Dr. Dominic D’Agostino discuss how diet and brain health are connected, how diet and gut health affect brain health, and how a ketogenic or other low-carbohydrate diets can be tailored to people’s specific needs.



Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠⁠https://levels.link/wnl⁠⁠



Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health.

Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health.



🎙 What Georgia Ede, MD & Dominic D’Agostino, PhD, discuss:

(06:51) — Dr. Georgia Ede describes her interest in nutritional science for mental health

(16:45) — Metabolic health is tied to brain health

(23:16) — A ketogenic diet vs medications for mental health

(27:19) — A ketogenic diet can be tailored to prevent side effects

(32:51) — Gut health and mental health are connected

(39:00) — Diet is highly individual

(42:02) —CGM can teach people how foods and diet strategies affect their health

(44:57) — Following a low-carbohydrate diet will generally reduce insulin levels and triglycerides

(47:40) — Some psychiatric symptoms have links to higher C-reactive protein levels

(48:42) — Dr. D’Agostino summarizes one of Dr. Ede’s studies on the ketogenic diet and mental health

(56:59) — A ketogenic diet may also help ease some menopause symptoms

⁠Transcripts & Show notes⁠

🔗 Helpful links:

Watch the conversation: ⁠⁠https://youtu.be/kBjBEjV0vqU⁠

Find us on YouTube: ⁠⁠https://youtube.com/levelshealth?sub_confirmation=1

Not all calories are equal. Tracking your macronutrient intake, using AI capabilities, can help you improve your body composition, facilitate weight loss, and boost exercise performance. The three macronutrients are protein, fat, and carbohydrates, with fiber a subset of carbs. Josh Clemente & Dr. Dominic D'Agostino discuss the new macros-tracking feature in the Levels app, the purpose and importance of each macronutrient, how to use macros-tracking in conjunction with biomarker data to improve health and fitness, and how easy the app’s AI functionality is to use.



Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠⁠⁠⁠⁠https://levels.link/wnl⁠⁠⁠⁠



Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health.

Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health.



🎙 What Josh Clemente & Dominic D'Agostino, PhD, discuss:

(09:03) — The importance of prioritizing protein intake

(17:03) — Why is tracking macros beneficial?

(21:11) — Each macronutrient has a different role in the body

(39:36) — The different functions of macros

(48:32) — Is excess protein a concern?

(54:55) — The problem with excess carbohydrates

(1:00:37) — Tracking macros can help you improve metabolic flexibility

(1:02:41) — The issue with overconsumption of carbohydrates

(1:17:18) — Is fiber a macronutrient?

(1:46:21) — Macros tracking in the Levels app

(1:49:50) — Tracking macros can help improve body composition and performance

Transcripts & Show notes

🔗 Helpful links:

Watch the conversation: https://youtu.be/wg76Q25Ngd4

Find us on YouTube: ⁠⁠⁠⁠⁠https://youtube.com/levelshealth?sub_confirmation=1⁠⁠

Fructose and its byproduct uric acid may play a role in the development of Alzheimer’s, thanks to an evolutionary adaptation hijacked by the modern diet. Fructose can be directly consumed, or the body can convert high-glycemic carbohydrates and other foods to fructose. Fructose suppresses some cognitive functions. Dr. Richard Johnson and Dr. Rob Lustig discuss a new study, of which Johnson was an author, on how fructose may be a potential driver in Alzheimer’s, and they hypothesize about fructose’s potential connection to the development of other conditions.



Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠https://levels.link/wnl⁠



🎙 What Richard Johnson, MD, & Rob Lustig, MD, discuss:

(09:50) — Fructose is the driver of some diseases that are on the rise in kids

(11:53) — Fructose is a driver of obesity and metabolic syndrome

(15:36) — Pharmaceutical treatments for Alzheimer’s disease aren’t as effective as researchers had hoped

(17:32)— The research focus of Alzheimer’s is slowly shifting to understanding insulin resistance in the brain

(20:41) — Is fructose a root cause of Alzheimer’s?

(26:26) — New research suggests fructose induces a foraging response

(28:20) — Fructose inhibits areas of the brain to encourage successful foraging

(46:48) — We need more research on fructose

(1:03:10) —Is fructose a factor in violence?

⁠Transcripts & Show notes⁠

Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health.



Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health.



👋 WHO WE ARE:

Levels helps you see how food affects your health. With real-time, personalized data gathered through biosensors like continuous glucose monitors (CGM), you learn which diet and lifestyle choices improve your metabolic health so you can live a longer, fuller, healthier life.



🔗 LINKS:

Could Alzheimer’s disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?: ⁠https://www.sciencedirect.com/science/article/abs/pii/S0002916523000047?dgcid=author⁠

Subscribe here on YouTube: ⁠https://youtube.com/levelshealth?sub_confirmation=1⁠

Gastrointestinal health, metabolic health, and fertility are all linked. The gut microbiome impacts other microbiomes in the body, which can then impact the ability to conceive. Our gut microbiomes are becoming less diverse through modern farming practices and the consumption of processed foods. Dr. Robin Rose and Ben Grynol discuss how gut microbiome testing can determine underlying factors of gastrointestinal distress and the lifestyle changes that can help address symptoms and even aid fertility.



Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠https://levels.link/wnl⁠



🎙 What Robin Rose, MD, & Ben Grynol discuss:

(08:05) — Gastrointestinal issues are associated with metabolic health issues

(08:56) — Many people lack gut microbiome diversity

(15:24) — Infertility in some people has links to the gut microbiome

(30:56) — PCOS and gut dysbiosis share a connection that’s still being researched

(32:26) — Restoring gut and metabolic health may help alleviate PCOS symptoms

(34:44) — Metagenomic testing assesses gut health

(39:47) — Gut health often requires balanced macronutrient intake

(49:14) — Regenerative farming practices could help us get more quality nutrients

(54:57) — Eliminating dairy and gluten may ease gastrointestinal symptoms

(56:29) — Sleep quality and quantity also inform gut health

⁠Transcript & Show Notes⁠

Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health.

Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health.

🔗 Helpful links:

Watch the conversation: ⁠https://youtu.be/SpW9znY3fkI⁠

Find us on YouTube: ⁠https://youtube.com/levelshealth?sub_confirmation=1⁠

High-carbohydrate diets and carbohydrate loading have been long-standing tenets of athletic training and competition, but newer research indicates a low-carbohydrate diet may be more beneficial for performance and overall health. Professor Tim Noakes and Josh Clemente discuss how a fat-adapted body can rely on fat as a fuel source at all exercise intensity levels, rather than burning mostly carbohydrates, and how such adaptation and dietary focus may reduce one’s risk of prediabetes and Type 2 diabetes.



Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠https://levels.link/wnl⁠



Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health.

Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health.

🎙 What Tim Noakes, MD, PhD, & Josh Clemente discuss:

(04:28) — Dr. Tim Noakes explains his career trajectory

(19:04) — An adapted body can rely on fat for all exercise intensities

(22:30) — The body will never get to a state of no glucose circulation

(23:28) — A delicate balance of macronutrients is likely necessary

(29:11) — Before the high-carbohydrate craze, elite athletes were fat adapted

(33:46) — Fat oxidation in muscle may have a protective effect against Type 2 diabetes

(36:39) — Exercise does not cancel out the risk for metabolic disease if diet isn’t accounted for

(47:25) — The body can cope with fasting

(54:32) — The high-carb training trend has been perpetuated by the carbohydrate industry

⁠Transcripts & Show notes⁠

🔗 Helpful links:

Find us on YouTube: ⁠https://youtube.com/levelshealth?sub_confirmation=1⁠

Your sleep routine is one of the most important aspects of your metabolic health. Look for multiple new shows per week on A Whole New Level, where we have in-depth conversations about metabolic health and how the Levels startup team builds a wellness movement from the ground up in the health and wellness tech industry.



Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠https://levels.link/wnl⁠



Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health.

Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health.

🎙 What Ben Grynol and Mike Haney discuss:

(02:36) - A study about sleep and metabolic health

(03:26) - The benefits of sleep for metabolic health

(05:24) - Sleeping at home

(05:24) - Standardized meals

(07:20) - How glucose levels affect sleep quality and duration

(12:50) - What you eat matters

(14:37) - Sleep quality and glucose

(18:06) - Sleep is the most important thing you control

(18:55) - Don’t sacrifice sleep

(20:08) - The importance of consistency

(25:29) - Compounding effects work both ways

⁠Transcripts and Show Notes⁠

🔗 Helpful links:

How does sleep affect blood sugar?: ⁠https://levelshealth.com/blog/how-sleep-impacts-metabolic-health-glucose-levels-cgm⁠

Find us on YouTube: ⁠https://youtube.com/levelshealth?sub_confirmation=1⁠